Odontogenic Keratocyst (OKC)
Histogenesis
- Primordial Origin
Arises from dental lamina rests. - Dentigerous Origin
Arises from the reduced enamel epithelium of the dental follicle.
Notable Features
Clinical Features
- Peak Incidence: 2nd and 3rd decades.
- Male Predilection.
- Common Sites:
- Mandible: Majority occur in the ramus-third molar area, followed by 1st & 2nd molars, then anterior mandible.
- Maxilla: 3rd molar > cuspid region.
- Bony Expansion: Causes antero-posterior bony expansion.
- Some may rupture and leak keratin, causing pain and swelling due to an inflammatory reaction.
- Displaces the inferior alveolar nerve bundle to the inferior border but does not affect nerve sensation.
Radiological Features
- Unilocular Radiolucency: Most commonly seen.
- Multilocular Radiolucency: Represents a central cavity containing satellite cysts. Multilocularity is associated with larger lesions.
- Variants
- Replacement
- Envelopment
- Extraneous
- Collateral
Histological Features
Lined by stratified squamous epithelium with a flat epithelium-connective tissue junction (no rete ridges).
Parakeratinised Type:
- Corrugated surface.
- Basal cell layer: Hyperchromatic, cuboidal/columnar shape.
- Palisaded nuclei.
- Fibrous wall contains epithelial islands → central keratinisation → Daughter/Satellite cysts.
- Cystic lumen contains keratin.
Orthokeratinised Type:
- Thin lining with a flat orthokeratinised surface.
- Basal cells: Not hyperchromatic and not palisaded.
- Satellite cysts are absent, hence referred to as keratinizing odontogenic cysts.
- No recurrence.
Treatment Options
- Marsupialisation is followed by enucleation.
- Enucleation, followed by cryosurgery.
- Enucleation with adjunctive chemical cauterization using Carnoy’s solution alongside excision of the overlying attached mucosa.
- Radical excision: Reserved for multiple recurrent lesions.
Consultation
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Dr. Shweta Richardson
BDS
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Dr. Aprjeetha
Dr. Harish
Dr. Pearlin
Dr. Rishita Lamechwal
M.D.S.
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