Odontogenic Keratocyst (OKC)

Histogenesis

  • Primordial Origin
    Arises from dental lamina rests.
  • Dentigerous Origin
    Arises from the reduced enamel epithelium of the dental follicle.
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Notable Features

Clinical Features

  • Peak Incidence: 2nd and 3rd decades.
  • Male Predilection.
  • Common Sites: 
    1. Mandible: Majority occur in the ramus-third molar area, followed by 1st & 2nd molars, then anterior mandible.
    2. Maxilla: 3rd molar > cuspid region.
  • Bony Expansion: Causes antero-posterior bony expansion.
  • Some may rupture and leak keratin, causing pain and swelling due to an inflammatory reaction.
  • Displaces the inferior alveolar nerve bundle to the inferior border but does not affect nerve sensation.

Radiological Features

  • Unilocular Radiolucency: Most commonly seen.
  • Multilocular Radiolucency: Represents a central cavity containing satellite cysts. Multilocularity is associated with larger lesions.
  • Variants
    1. Replacement
    2. Envelopment
    3. Extraneous
    4. Collateral

Histological Features

Lined by stratified squamous epithelium with a flat epithelium-connective tissue junction (no rete ridges).

Parakeratinised Type:
  • Corrugated surface.
  • Basal cell layer: Hyperchromatic, cuboidal/columnar shape.
  • Palisaded nuclei.
  • Fibrous wall contains epithelial islands → central keratinisation → Daughter/Satellite cysts.
  • Cystic lumen contains keratin.
Orthokeratinised Type:
  • Thin lining with a flat orthokeratinised surface.
  • Basal cells: Not hyperchromatic and not palisaded.
  • Satellite cysts are absent, hence referred to as keratinizing odontogenic cysts.
  • No recurrence.

Treatment Options

  1. Marsupialisation is followed by enucleation.
  2. Enucleation, followed by cryosurgery.
  3. Enucleation with adjunctive chemical cauterization using Carnoy’s solution alongside excision of the overlying attached mucosa.
  4. Radical excision: Reserved for multiple recurrent lesions.
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Dr. Sunil Richardson
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Dr. Shweta Richardson
BDS
Cosmetic Dental Surgeon & Adminstrator
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Dr. Rosemary Mathew
General Dental Surgeon
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Dr. Aprjeetha
Oral & Maxillofacial Surgeon
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Dr. Harish
Oral & Maxillofacial Surgeon
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Dr. Pearlin
General Dental Surgeon
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Dr. Rishita Lamechwal
M.D.S.
Oral & Maxillofacial Surgeon

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